IPS HEART
  • Sign In

  • My Account
  • Signed in as:

  • filler@godaddy.com


  • My Account
  • Sign out

  • Home
  • About Us
  • Our Approach
  • Our Pipeline
  • Why Heart Disease?
  • Why DMD?
  • Platform
  • Publications
  • Clinical Efficacy
  • More
    • Home
    • About Us
    • Our Approach
    • Our Pipeline
    • Why Heart Disease?
    • Why DMD?
    • Platform
    • Publications
    • Clinical Efficacy
IPS HEART

Signed in as:

filler@godaddy.com

  • Home
  • About Us
  • Our Approach
  • Our Pipeline
  • Why Heart Disease?
  • Why DMD?
  • Platform
  • Publications
  • Clinical Efficacy

Account


  • My Account
  • Sign out


  • Sign In
  • My Account

FEATURED MANUSCRIPTS

Cardiac Progenitors Induced from Human Induced Pluripotent Stem Cells with Cardiogenic Small Molecule Effectively Regenerate Infarcted Hearts

miRNAs in Extracellular Vesicles from iPS-Derived Cardiac Progenitor Cells Effectively Reduce Fibrosis and Promote Angiogenesis in Infarcted Heart

miRNAs in Extracellular Vesicles from iPS-Derived Cardiac Progenitor Cells Effectively Reduce Fibrosis and Promote Angiogenesis in Infarcted Heart

Cardiac progenitor cells (CPCs) being multipotent offer a promising source for cardiac repair due to their ability to proliferate and multiply into cardiac lineage cells. Here, we explored a novel strategy for human CPCs generation from human induced pluripotent stem cells (hiPSCs) using a cardiogenic small molecule, isoxazole (ISX-9) and

Cardiac progenitor cells (CPCs) being multipotent offer a promising source for cardiac repair due to their ability to proliferate and multiply into cardiac lineage cells. Here, we explored a novel strategy for human CPCs generation from human induced pluripotent stem cells (hiPSCs) using a cardiogenic small molecule, isoxazole (ISX-9) and their ability to grow in the scar tissue for functional improvement in the infarcted myocardium.

Read more

miRNAs in Extracellular Vesicles from iPS-Derived Cardiac Progenitor Cells Effectively Reduce Fibrosis and Promote Angiogenesis in Infarcted Heart

miRNAs in Extracellular Vesicles from iPS-Derived Cardiac Progenitor Cells Effectively Reduce Fibrosis and Promote Angiogenesis in Infarcted Heart

miRNAs in Extracellular Vesicles from iPS-Derived Cardiac Progenitor Cells Effectively Reduce Fibrosis and Promote Angiogenesis in Infarcted Heart

Cardiac stem cell therapy offers the potential to ameliorate postinfarction remodeling and development of heart failure but requires optimization of cell-based approaches. Cardiac progenitor cells (CPCs) induction by ISX-9, a small molecule possessing antioxidant, prosurvival, and regenerative properties, represents an attractive potentia

Cardiac stem cell therapy offers the potential to ameliorate postinfarction remodeling and development of heart failure but requires optimization of cell-based approaches. Cardiac progenitor cells (CPCs) induction by ISX-9, a small molecule possessing antioxidant, prosurvival, and regenerative properties, represents an attractive potential approach for cell-based cardiac regenerative therapy. Here, we report that extracellular vesicles (EV) secreted by ISX-9-induced CPCs (EV-CPCISX-9) faithfully recapitulate the beneficial effects of their parent CPCs with regard to postinfarction remodeling. 

Read more

Pluripotent stem cell-induced skeletal muscle progenitor cells with givinostat promote myoangiogenesis

miRNAs in Extracellular Vesicles from iPS-Derived Cardiac Progenitor Cells Effectively Reduce Fibrosis and Promote Angiogenesis in Infarcted Heart

Pluripotent stem cell-induced skeletal muscle progenitor cells with givinostat promote myoangiogenesis

Duchenne muscular dystrophy (DMD) is caused by mutations of the gene that encodes the protein dystrophin. A loss of dystrophin leads to severe and progressive muscle wasting in both skeletal and heart muscles. Human induced pluripotent stem cells (hiPSCs) and their derivatives offer important opportunities to treat a number of diseases. H

Duchenne muscular dystrophy (DMD) is caused by mutations of the gene that encodes the protein dystrophin. A loss of dystrophin leads to severe and progressive muscle wasting in both skeletal and heart muscles. Human induced pluripotent stem cells (hiPSCs) and their derivatives offer important opportunities to treat a number of diseases. Here, we investigated whether givinostat (Givi), a histone deacetylase inhibitor, with muscle differentiation properties could reprogram hiPSCs into muscle progenitor cells (MPC) for DMD treatment. 

Read more

Press

GIVI-MPC earns FDA orphan designation to treat DMD. Source: Muscular Dystrophy News

GIVI-MPC earns FDA orphan designation to treat DMD. Source: Muscular Dystrophy News

GIVI-MPC earns FDA orphan designation to treat DMD. Source: Muscular Dystrophy News

Read more

IPS HEART Aims to Use Induced Pluripotent Stem Cells to Treat Heart Attack Source: Biobanking

GIVI-MPC earns FDA orphan designation to treat DMD. Source: Muscular Dystrophy News

GIVI-MPC earns FDA orphan designation to treat DMD. Source: Muscular Dystrophy News

Read more

Copyright © 2014 IPS HEART - All Rights Reserved.